As people age, their immune systems naturally become less effective at fighting off infections and reacting to vaccines. This decline, known as immunosenescence, leaves older adults more vulnerable to illnesses like the influenza, framer.website respiratory infections, and complications from viruses such as the coronavirus. One compound that has recently drawn attention for its potential to bolster immune function in aging populations is NMN. NMN is a precursor molecule to NAD+, a cellular compound essential for cellular energy production and genomic stability. Research suggests that as we grow older, levels of NAD+ decline, which may contribute to reduced immune surveillance. By increasing NAD+ concentration, NMN may help restore some of the cellular processes that keep the immune system strong.

Studies in animal models and pilot trials have shown that NMN supplementation can enhance the function of immune cells such as adaptive immune cells and NK cells. These cells play a critical role in recognizing and eliminating pathogen-infected cells. In older adults, these cells often become exhausted or hyporesponsive. NMN appears to help revitalize them by enhancing mitochondrial efficiency and curbing chronic inflammatory signals. Chronic low-grade inflammation is another key feature of senescence that can suppress immunity, and NMN has been connected to decreased expression of pro-inflammatory cytokines in several studies.

Additionally, NMN may enhance the body’s response to immunizations. Older adults often exhibit diminished seroconversion after vaccination, which compromises immunity. Early evidence suggests that when combined with vaccination, NMN supplementation could lead to stronger and longer-lasting immune memory. This is especially promising for flu and COVID vaccines, where protection declines with age.

While wider controlled trials are needed to confirm these findings, the preliminary results are promising. NMN is easily accepted in older adults with minimal adverse reactions. It is not a replacement for essential wellness behaviors like nutrient-rich eating, consistent physical activity, and sufficient rest. However, it may serve as a supportive tool to help the declining defenses function more efficiently. As research continues, NMN holds potential as part of a broader strategy to help older adults stay healthier in the face of disease.