NMN is being studied as a supportive intervention for individuals with prediabetes. Prediabetes refers to a condition of impaired glucose tolerance—a critical signal that diet and activity adjustments must be made to prevent progression to type 2 diabetes. Studies examining NMN suggest it may improve the body’s response to insulin and optimize metabolic function by boosting levels of NAD+, a coenzyme fundamental to mitochondrial function.

NAD+ concentrations diminish over time, especially in aging populations, and this reduction is significantly accelerated in those with metabolic dysfunction. The body uses NMN to synthesize NAD+, enabling more efficient NAD+ generation. Higher NAD+ levels have been associated in clinical studies with improved glucose homeostasis, stronger mitochondrial performance, and lower systemic inflammation, all of which aid in reversing insulin resistance.

Research conducted on aging prediabetic populations have demonstrated visit that regular supplementation with NMN enhanced tissue sensitivity to insulin, primarily in peripheral tissues. This means cells respond better to insulin signals, thereby contributing to lower overall blood sugar. Initial evidence is positive, most existing studies are limited in scale, and extended studies with diverse populations must be conducted to confirm therapeutic efficacy and identify ideal dosing protocols.

NMN does not function as a replacement for clinically proven interventions such as a low-glycemic, whole-food eating plan, consistent physical activity, and healthy weight loss. Rather, it may complement existing efforts for those seriously committed to lifestyle change. Those interested in NMN are strongly advised to seek medical advice, especially with concurrent prescriptions, to avoid potential interactions.

Most users report minimal side effects in the studies available to date. However, because the supplement market lacks strict oversight, selecting a trusted, transparent brand is essential to ensure purity.

The ultimate goal for prediabetics is to restore normal glucose levels and preventing the onset of type 2 diabetes. NMN holds potential as part of an integrated plan, long-term success depends on consistent diet, exercise, and clinician oversight. NMN could enhance cellular resilience, but it cannot replace core health practices.